Development of Circumventricular Organs in the Mirror of Zebrafish Enhancer-Trap Transgenics.

ABSTRACT: The circumventricular organs (CVOs) are small structures lining the cavities of brain ventricular system. They are associated with the semitransparent regions of the blood-brain barrier (BBB). Hence it is thought that CVOs mediate biochemical signaling and cell exchange between the brain and systemic blood. Their classification is still controversial and development not fully understood largely due to an absence of tissue-specific molecular markers. In a search for molecular determinants of CVOs we studied the green fluorescent protein (GFP) expression pattern in several zebrafish enhancer trap transgenics including Gateways (ET33-E20) that has been instrumental in defining the development of choroid plexus. In Gateways the GFP is expressed in regions of the developing brain outside the ch

SUBMITTER: Garcia-Lecea M 

PROVIDER: S-EPMC5770639 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature