Glutamine Transport and Mitochondrial Metabolism in Cancer Cell Growth.

ABSTRACT: The concept that cancer is a metabolic disease is now well acknowledged: many cancer cell types rely mostly on glucose and some amino acids, especially glutamine for energy supply. These findings were corroborated by overexpression of plasma membrane nutrient transporters, such as the glucose transporters (GLUTs) and some amino acid transporters such as ASCT2, LAT1, and ATB^0,+, which became promising targets for pharmacological intervention. On the basis of their sodium-dependent transport modes, ASCT2 and ATB0⁺ have the capacity to sustain glutamine need of cancer cells; while LAT1, which is sodium independent will have the role of providing cancer cells with some amino acids with plausible signaling roles. According to the metabolic reprogramming of many types of ca

SUBMITTER: Scalise M 

PROVIDER: S-EPMC5770653 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature