Computational Model of Antidepressant Response Heterogeneity as Multi-pathway Neuroadaptation.

ABSTRACT: Current hypotheses cannot fully explain the clinically observed heterogeneity in antidepressant response. The therapeutic latency of antidepressants suggests that therapeutic outcomes are achieved not by the acute effects of the drugs, but rather by the homeostatic changes that occur as the brain adapts to their chronic administration. We present a computational model that represents the known interactions between the monoaminergic neurotransmitter-producing brain regions and associated non-monoaminergic neurotransmitter systems, and use the model to explore the possible ways in which the brain can homeostatically adjust to chronic antidepressant administration. The model also represents the neuron-specific neurotransmitter receptors that are known to adjust their strengths (expressions or

SUBMITTER: Camacho MB 

PROVIDER: S-EPMC5770730 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature