Stress and Disease Onset in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.

ABSTRACT:

Objective

To explore the potential contribution of stress as a trigger for disease onset in patients with antineutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV).

Methods

53 AAV and 85 rheumatoid arthritis (RA) patients as well as 53 healthy controls (HC) were thoroughly asked for the number and impact of stressful life events, coping strategies, and available social support 12 months prior to disease onset. Anxiety, depression, personality dimensions, insomnia, and fatigue were also determined.

Results

AAV patients reported higher scoring of the impact of stressful life events compared to the RA and HC group prior to disease onset (2.8 ± 3.1 vs 1.8 ± 2.1 vs 1.7 ± 2.3, p-values: 0.047 and 0.053, respectively). While the number of reported stressf

SUBMITTER: Golemati CV 

PROVIDER: S-EPMC5770743 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature