Complement Gene Expression Correlates with Superior Frontal Cortical Thickness in Humans.

ABSTRACT: Recent work suggests that genes encoding complement proteins that are active in the innate immune system may confer risk for schizophrenia by disrupting typical synaptic pruning in late adolescence. Alterations in the complement pathway may contribute to aberrant cortical thinning in schizophrenia prodromes and reduced prefrontal cortical thickness in chronic schizophrenia patients; however, this theory needs to be translated to humans. We conducted a series of analyses in a sample of adult Swedish twins enriched for schizophrenia (N=129) to assess the plausibility of a relationship between complement gene expression and cortical thickness that could go awry in the etiology of schizophrenia. First, we identified that peripheral mRNA expression levels of two complement genes (C5, SERPING1)

SUBMITTER: Allswede DM 

PROVIDER: S-EPMC5770755 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature