Decreased Brain pH as a Shared Endophenotype of Psychiatric Disorders.

ABSTRACT: Although the brains of patients with schizophrenia and bipolar disorder exhibit decreased brain pH relative to those of healthy controls upon postmortem examination, it remains controversial whether this finding reflects a primary feature of the diseases or is a result of confounding factors such as medication and agonal state. To date, systematic investigation of brain pH has not been undertaken using animal models that can be studied without confounds inherent in human studies. In the present study, we first reevaluated the pH of the postmortem brains of patients with schizophrenia and bipolar disorder by conducting a meta-analysis of existing data sets from 10 studies. We then measured pH, lactate levels, and related metabolite levels in brain homogenates from five neurodevelopmental mo

SUBMITTER: Hagihara H 

PROVIDER: S-EPMC5770757 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature