Perinatal Immune Activation Produces Persistent Sleep Alterations and Epileptiform Activity in Male Mice.

ABSTRACT: Increasing evidence suggests a role for inflammation in neuropsychiatric conditions, including autism spectrum disorder (ASD). Previous work in rodents has established that immune activation during critical developmental periods can cause phenotypes that reproduce core features of ASD, including decreased social interaction, aberrant communication, and increased repetitive behavior. In humans, ASD is frequently associated with comorbid medical conditions including sleep disorders, motor hyperactivity, and seizures. Here we use a 'two-hit' immune-activation paradigm to determine whether perinatal immune activation can also produce these comorbid features in mice. In this paradigm, we treated timed-pregnant mice with polyinosinic:polycytidylic acid (Poly I:C), which simulates a viral infecti

SUBMITTER: Missig G 

PROVIDER: S-EPMC5770773 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature