Age-associated microRNA expression in human peripheral blood is associated with all-cause mortality and age-related traits.

ABSTRACT: Recent studies provide evidence of correlations of DNA methylation and expression of protein-coding genes with human aging. The relations of microRNA expression with age and age-related clinical outcomes have not been characterized thoroughly. We explored associations of age with whole-blood microRNA expression in 5221 adults and identified 127 microRNAs that were differentially expressed by age at P < 3.3 × 10^-4 (Bonferroni-corrected). Most microRNAs were underexpressed in older individuals. Integrative analysis of microRNA and mRNA expression revealed changes in age-associated mRNA expression possibly driven by age-associated microRNAs in pathways that involve RNA processing, translation, and immune function. We fitted a linear model to predict 'microRNA age' that incorporated

SUBMITTER: Huan T 

PROVIDER: S-EPMC5770777 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature