Comparative proteomic profiling reveals a role for Cisd2 in skeletal muscle aging.

ABSTRACT: Skeletal muscle has emerged as one of the most important tissues involved in regulating systemic metabolism. The gastrocnemius is a powerful skeletal muscle composed of predominantly glycolytic fast-twitch fibers that are preferentially lost among old age. This decrease in gastrocnemius muscle mass is remarkable during aging; however, the underlying molecular mechanism is not fully understood. Strikingly, there is a ~70% decrease in Cisd2 protein, a key regulator of lifespan in mice and the disease gene for Wolfram syndrome 2 in humans, within the gastrocnemius after middle age among mice. A proteomics approach was used to investigate the gastrocnemius of naturally aged mice, and this was compared to the autonomous effect of Cisd2 on gastrocnemius aging using muscle-specific Cisd2 knockout

SUBMITTER: Huang YL 

PROVIDER: S-EPMC5770874 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature