Do biological disease-modifying antirheumatic drugs reduce the spinal fracture risk related to ankylosing spondylitis? A longitudinal multiregistry matched cohort study.

ABSTRACT:

Objectives

Ankylosing spondylitis (AS) is associated with an increased spinal fracture risk due to the loss of elasticity in spinal motion segments. With the introduction of biological disease-modifying antirheumatic drug (bDMARD) treatment for AS, the individual course of the disease has been ameliorated. This study aims to examine the association of bDMARD treatment and risk of spinal fracture.

Design

Longitudinal population-based multiregistry observational matched cohort study.

Setting

Swedish Patient Registry 1987-2014 and Swedish Prescribed Drugs Registry 2005-2014.

Participants

Included were patients ≥18 years of age receiving treatment at a healthcare facility for the primary diagnosis of AS. About 1352 patients received more than one prescription of bD

SUBMITTER: Robinson Y 

PROVIDER: S-EPMC5770921 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature