Risk of autism spectrum disorder in offspring following paternal use of selective serotonin reuptake inhibitors before conception: a population-based cohort study.

ABSTRACT:

Objective

The present study aimed to examine the association between paternal selective serotonin reuptake inhibitor (SSRI) use before conception and the risk of autism spectrum disorder (ASD) in offspring.

Design

A population-based cohort study.

Methods

We conducted a cohort study of 669 922 children born from 1998 to 2008, with follow-up throughout 2013. Based on Danish national registers, we linked information on paternal use of SSRIs, ASD diagnosed in children and a range of potential confounders. The children whose fathers used SSRIs during the last 3 months prior to conception were identified as the exposed. Cox regression model was used to estimate the HR for ASD in children.

Results

Compared with unexposed children, the exposed had a 1.62-fold higher ri

SUBMITTER: Yang F 

PROVIDER: S-EPMC5770959 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature