Regulation of Adult CNS Axonal Regeneration by the Post-transcriptional Regulator Cpeb1.

ABSTRACT: Adult mammalian central nervous system (CNS) neurons are unable to regenerate following axonal injury, leading to permanent functional impairments. Yet, the reasons underlying this regeneration failure are not fully understood. Here, we studied the transcriptome and translatome shortly after spinal cord injury. Profiling of the total and ribosome-bound RNA in injured and naïve spinal cords identified a substantial post-transcriptional regulation of gene expression. In particular, transcripts associated with nervous system development were down-regulated in the total RNA fraction while remaining stably loaded onto ribosomes. Interestingly, motif association analysis of post-transcriptionally regulated transcripts identified the cytoplasmic polyadenylation element (CPE) as enriched in a subs

SUBMITTER: Lou WP 

PROVIDER: S-EPMC5770975 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature