Chemokine ligand-receptor interactions critically regulate cutaneous wound healing.

ABSTRACT:

Background

Wound healing represents a dynamic process involving directional migration of different cell types. Chemokines, a family of chemoattractive proteins, have been suggested to be key players in cell-to-cell communication and essential for directed migration of structural cells. Today, the role of the chemokine network in cutaneous wound healing is not fully understood. Unraveling the chemokine-driven communication pathways in this complex process could possibly lead to new therapeutic strategies in wound healing disorders.

Methods

We performed a systematic, comprehensive time-course analysis of the expression and function of a broad variety of cytokines, growth factors, adhesion molecules, matrixmetalloproteinases and chemokines in a murine cutaneous wound healing mo

SUBMITTER: Bunemann E 

PROVIDER: S-EPMC5771017 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature