Rapid HIV disease progression following superinfection in an HLA-B*27:05/B*57:01-positive transmission recipient.

ABSTRACT:

Background

The factors determining differential HIV disease outcome among individuals expressing protective HLA alleles such as HLA-B*27:05 and HLA-B*57:01 remain unknown. We here analyse two HIV-infected subjects expressing both HLA-B*27:05 and HLA-B*57:01. One subject maintained low-to-undetectable viral loads for more than a decade of follow up. The other progressed to AIDS in < 3 years.

Results

The rapid progressor was the recipient within a known transmission pair, enabling virus sequences to be tracked from transmission. Progression was associated with a 12% Gag sequence change and 26% Nef sequence change at the amino acid level within 2 years. Although next generation sequencing from early timepoints indicated that multiple CD8+ cytotoxic T lymphocyte (CTL) escape mut

SUBMITTER: Brener J 

PROVIDER: S-EPMC5771019 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature