Atherosclerosis is exacerbated by chitinase-3-like-1 in amyloid precursor protein transgenic mice.

ABSTRACT: Although the important role of amyloid precursor protein (APP) in vascular diseases associated with Alzheimer's disease (AD) has been demonstrated, the underlying molecular mechanisms and physiological consequences are unclear. We aimed to evaluate vascular inflammation and atherosclerosis in Swedish mutant of human APP transgenic (APPsw-Tg) and ApoE^-/-/APPsw-Tg mice. We also aimed to explore the mechanisms underlying any changes observed in these mice compared with non-Tg controls. Methods: The transgenic and non-Tg mouse strains were subjected to partial ligation of the left carotid artery to induce atherosclerotic changes, which were measured using histological approaches, immunohistochemistry, quantitative polymerase chain reaction, and gene expression microarr

SUBMITTER: Jung YY 

PROVIDER: S-EPMC5771091 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature