Exploring the Link between Nucleosome Occupancy and DNA Methylation.

ABSTRACT: Near promoters, both nucleosomes and CpG sites form characteristic spatial patterns. Previously, nucleosome depleted regions were observed upstream of transcription start sites and nucleosome occupancy was reported to correlate both with CpG density and the level of CpG methylation. Several studies imply a causal link where CpG methylation might induce nucleosome formation, whereas others argue the opposite, i.e., that nucleosome occupancy might influence CpG methylation. Correlations are indeed evident between nucleosomes, CpG density and CpG methylation-at least near promoter sites. It is however less established whether there is an immediate causal relation between nucleosome occupancy and the presence of CpG sites-or if nucleosome occupancy could be influenced by other factors. In this

SUBMITTER: Lovkvist C 

PROVIDER: S-EPMC5771128 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature