Influence of Interleukin-6 (174G/C) Gene Polymorphism on Obesity in Egyptian Children.

ABSTRACT: BACKGROUND:Obesity is a multi-factorial chronic disorder. A considerable number of studies have been performed to figure out whether there is an association between obesity and polymorphisms of gene IL-6 (174G/C), but the results are equivocal. AIM:This study aimed to find out whether the IL-6 (174G/C) gene was associated with the risk of developing obesity in Egyptian children. SUBJECTS AND METHODS:The study included 149 children and adolescents with age ranged between 9.5 - 18 years. Eighty-five of them were obese which BMIZ-score is > 2, and sixty-four children with BMIZ-score ≤ 2 served as control group. Serum level of IL-6 and genetic analysis for IL-6 (174G/C) gene polymorphism were done. RESULTS:Obese children had significantly higher serum levels of IL-6 as compared to those of con

SUBMITTER: Ibrahim OM 

PROVIDER: S-EPMC5771281 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature