ABCA7 and risk of dementia and vascular disease in the Danish population.

ABSTRACT:

Objective

ATP-binding-cassette transporter A7(ABCA7) is suggested to be involved in lipid transport as well as in phagocytosis of amyloid-β in the brain. We tested the hypothesis that a common genetic variant in ABCA7 is associated with dementia, ischemic heart disease, ischemic cerebrovascular disease, and with lipid levels in the general population, independent of the common apolipoprotein E(APOE) genotype.

Methods

For this purpose, we genotyped a common genetic variant in ABCA7, identified in genome-wide-association-studies of Alzheimer's disease, in 104,258 individuals from the Danish general population, and also meta-analyzed our results with publicly available consortia data.

Results

Multifactorially adjusted hazard ratios for

SUBMITTER: Kjeldsen EW 

PROVIDER: S-EPMC5771325 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature