Genomic Characterization of Renal Medullary Carcinoma and Treatment Outcomes.

ABSTRACT:

Background

Renal medullary carcinoma (RMC) is a rare and aggressive type of kidney cancer that primarily affects young adults with sickle cell trait; outcomes are poor despite treatment. Identifying molecular features of this tumor could provide biologic rationale for novel targeted therapies. The objective was to report on clinical outcomes with systemic therapy and characterize molecular features.

Patients and methods

This was a retrospective analysis on 36 patients given a pathologic diagnosis of RMC at one institution from 1995 to 2015. Tumors were analyzed for expression of SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1 (SMARCB1) through immunohistochemistry and for genomic alterations with fluorescence in situ hybridiz

SUBMITTER: Carlo MI 

PROVIDER: S-EPMC5771412 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature