Quorum Sensing Inhibition and Structure-Activity Relationships of β-Keto Esters.

ABSTRACT: Traditional therapeutics to treat bacterial infections have given rise to multi-drug resistant pathogens, which pose a major threat to human and animal health. In several pathogens, quorum sensing (QS)-a cell-cell communication system in bacteria-controls the expression of genes responsible for pathogenesis, thus representing a novel target in the fight against bacterial infections. Based on the structure of the autoinducers responsible for QS activity and other QS inhibitors, we hypothesize that β-keto esters with aryl functionality could possess anti-QS activity. A panel of nineteen β-keto ester analogs was tested for the inhibition of bioluminescence (a QS-controlled phenotype) in the marine pathogen Vibrio harveyi. Initial screening demonstrated the need of a phenyl ring at the C-3 pos

SUBMITTER: Forschner-Dancause S 

PROVIDER: S-EPMC5771494 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature