Analyses of Calcium-Independent Phospholipase A₂beta (iPLA₂β) in Biological Systems.

ABSTRACT: The Ca²⁺-independent phospholipases A₂ (iPLA₂s) are part of a diverse family of PLA₂s, manifest activity in the absence of Ca²⁺, are ubiquitous, and participate in a variety of biological processes. Among the iPLA₂s, the cytosolic iPLA₂β has received considerable attention and ongoing studies from various laboratories suggest that dysregulation of iPLA₂β can have a profound impact on the onset and/or progression of many diseases (e.g., cardiovascular, neurological, metabolic, autoimmune). Therefore, appropriate approaches are warranted to gain a better understanding of the role of iPLA₂β in vivo and its contribution to pathophysiology. Given that iPLA₂β is very labile, its basal ex

SUBMITTER: Barbour SE 

PROVIDER: S-EPMC5771648 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature