A Family Based Study of Carbon Monoxide and Nitric Oxide Signalling Genes and Preeclampsia.

ABSTRACT:

Background

Preeclampsia is thought to originate during placentation, with incomplete remodelling and perfusion of the spiral arteries leading to reduced placental vascular capacity. Nitric oxide (NO) and carbon monoxide (CO) are powerful vasodilators that play a role in the placental vascular system. Although family clustering of preeclampsia has been observed, the existing genetic literature is limited by a failure to consider both mother and child.

Methods

We conducted a nested case-control study within the Norwegian Mother and Child Birth Cohort of 1545 case-pairs and 995 control-pairs from 2540 validated dyads (2011 complete pairs, 529 missing mother or child genotype). We selected 1518 single-nucleotide polymorphisms (SNPs) with minor allele frequency >5% in NO and CO s

SUBMITTER: Bauer AE 

PROVIDER: S-EPMC5771849 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature