A unifying biology of sex steroid-induced apoptosis in prostate and breast cancers.

ABSTRACT: Prostate and breast cancer are the two cancers with the highest incidence in men and women, respectively. Here, we focus on the known biology of acquired resistance to antihormone therapy of prostate and breast cancer and compare laboratory and clinical similarities in the evolution of the disease. Laboratory studies and clinical observations in prostate and breast cancer demonstrate that cell selection pathways occur during acquired resistance to antihormonal therapy. Following sex steroid deprivation, both prostate and breast cancer models show an initial increased acquired sensitivity to the growth potential of sex steroids. Subsequently, prostate and breast cancer cells either become dependent upon the antihormone treatment or grow spontaneously in the absence of hormones. Paradoxicall

SUBMITTER: Maximov PY 

PROVIDER: S-EPMC5771961 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature