Propofol-induced Changes in α-β Sensorimotor Cortical Connectivity.

ABSTRACT:

Background

Anesthetics are believed to alter functional connectivity across brain regions. However, network-level analyses of anesthesia, particularly in humans, are sparse. The authors hypothesized that propofol-induced loss of consciousness results in functional disconnection of human sensorimotor cortices underlying the loss of volitional motor responses.

Methods

The authors recorded local field potentials from sensorimotor cortices in patients with Parkinson disease (N = 12) and essential tremor (N = 7) undergoing deep brain stimulation surgery, before and after propofol-induced loss of consciousness. Local spectral power and interregional connectivity (coherence and imaginary coherence) were evaluated separately across conditions for the two populations.

Results

SUBMITTER: Malekmohammadi M 

PROVIDER: S-EPMC5771969 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature