Whole genome sequence analyses of brain imaging measures in the Framingham Study.

ABSTRACT: OBJECTIVE:We sought to identify rare variants influencing brain imaging phenotypes in the Framingham Heart Study by performing whole genome sequence association analyses within the Trans-Omics for Precision Medicine Program. METHODS:We performed association analyses of cerebral and hippocampal volumes and white matter hyperintensity (WMH) in up to 2,180 individuals by testing the association of rank-normalized residuals from mixed-effect linear regression models adjusted for sex, age, and total intracranial volume with individual variants while accounting for familial relatedness. We conducted gene-based tests for rare variants using (1) a sliding-window approach, (2) a selection of functional exonic variants, or (3) all variants. RESULTS:We detected new loci in 1p21 for cerebral volume (m

SUBMITTER: Sarnowski C 

PROVIDER: S-EPMC5772158 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature