Impact of tissue kinetic heterogeneity on PET quantification: case study with the L-[1-11C]leucine PET method for cerebral protein synthesis rates.

ABSTRACT: Functional quantification with PET is generally based on modeling that assumes tissue regions are kinetically homogeneous. Even in regions sufficiently small to approach homogeneity, spillover due to resolution limitations of PET scanners may introduce heterogeneous kinetics into measured data. Herein we consider effects of kinetic heterogeneity at the smallest volume accessible, the single image voxel. We used L-[1-11C]leucine PET and compared rates of cerebral protein synthesis (rCPS) estimated voxelwise with methods that do (Spectral Analysis Iterative Filter, SAIF) and do not (Basis Function Method, BFM) allow for kinetic heterogeneity. In high resolution PET data with good counting statistics BFM produced estimates of rCPS comparable to SAIF, but at lower computational cost; thus the

SUBMITTER: Veronese M 

PROVIDER: S-EPMC5772379 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature