Buprenorphine-naloxone treatment responses differ between young adults with heroin and prescription opioid use disorders.

ABSTRACT:

Background and objectives

Opioid use disorder among young adults is rising sharply with an increase in morbidity and mortality. This study examined differences in treatment response to a fixed dose of buprenorphine-naloxone between heroin (HU) and prescriptions opioids (POU) users.

Methods

Eighty opioid dependent young adults (M = 22 years) were treated with buprenorphine-naloxone 16-4 mg/day for 8 weeks. Differences between HU (N = 17) and POU (N = 63) on changes in weekly opioid use, opioid craving, withdrawal, and depression symptoms were analyzed with mixed-effects regression models.

Results

The HU had an overall mean proportion of weekly opioid use of .32 (SD = .14) compared to POU's weekly mean of .24 (SD = .15) showing a significant main effect (Z = 2.21, p = .

SUBMITTER: Romero-Gonzalez M 

PROVIDER: S-EPMC5772882 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature