Immunological biomarkers associated with brain structure and executive function in late-life depression: exploratory pilot study.

ABSTRACT:

Objective

Several immunological biomarkers are altered in late-life major depressive disorder (LLD). Immunological alterations could contribute to LLD's consequences, but little is known about the relations between specific immunological biomarkers and brain health in LLD. We performed an exploratory pilot study to identify, from several candidates, the specific immunological biomarkers related to important aspects of brain health that are altered in LLD (brain structure and executive function).

Methods

Adults (n = 31) were at least 60 years old and had major depressive disorder. A multiplex immunoassay assessed 13 immunological biomarkers, and we examined their associations with structural MRI (grey matter volume and white matter hyperintensity volume (WMH)) and executive f

SUBMITTER: Smagula SF 

PROVIDER: S-EPMC5772975 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature