Assessment of serum pharmacokinetics and urinary excretion of albendazole and its metabolites in human volunteers.

ABSTRACT:

Background

Soil Transmitted Helminth (STH) infections negatively impact physical and mental development in human populations. Current WHO guidelines recommend morbidity control of these infections through mass drug administration (MDA) using albendazole (ABZ) or mebendazole. Despite major reductions in STH associated morbidity globally, not all programs have demonstrated the expected impact on prevalence of parasite infections. These therapeutic failures may be related to poor programmatic coverage, suboptimal adherence or the exposure of parasites to sub-therapeutic drug concentrations. As part of the DeWorm3 project, we sought to characterize the serum disposition kinetics and pattern of urinary excretion of ABZ and its main metabolites ABZ sulphoxide (ABZSO) and ABZ sulphone (AB

SUBMITTER: Ceballos L 

PROVIDER: S-EPMC5773000 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature