Ceramides in tracheal aspirates of preterm infants: Marker for bronchopulmonary dysplasia.

ABSTRACT:

Background

In an experimental mouse model we showed that ceramides play a role in the pathogenesis of bronchopulmonary dysplasia (BPD) and are a potential target for therapeutic intervention. We investigated whether ceramides are detectable in tracheal aspirates (TAs) of preterm infants and differ between infants with or without BPD.

Methods

Infants born ≤ 32 weeks of gestational age in need of mechanical ventilation in the first week of life were included. TAs were obtained directly after intubation and at day 1, 3, 5, 7, and 14. Ceramide concentrations were measured by tandem mass spectrometry. At 36 weeks postmenstrual age BPD was defined as having had ≥ 28 days supplemental oxygen.

Results

122 infants were included, of which 14 died and 41 developed BPD. All infan

SUBMITTER: van Mastrigt E 

PROVIDER: S-EPMC5773003 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature