Insights into the genetics of blood pressure in black South African individuals: the Birth to Twenty cohort.

ABSTRACT:

Background

Cardiovascular diseases (CVDs) are the leading cause of non-communicable disease deaths globally, with hypertension being a major risk factor contributing to CVDs. Blood pressure is a heritable trait, with relatively few genetic studies having been performed in Africans. This study aimed to identify genetic variants associated with variance in systolic (SBP) and diastolic (DBP) blood pressure in black South Africans.

Methods

Genotyping was performed using the Metabochip in a subset of participants (mixed sex; median age 17.9) and their adult female caregivers (median age 41.0) from the Birth to Twenty cohort (n = 1947). Data were analysed as a merged dataset (all participants and caregivers together) in GEMMA (v0.94.1) using univariate linear mixed models, incorpo

SUBMITTER: Hendry LM 

PROVIDER: S-EPMC5773038 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature