Alzheimer's Disease Biomarkers and Future Decline in Cognitive Normal Older Adults.

ABSTRACT:

Background

Identifying older adults at risk of cognitive decline represents a challenge as Alzheimer's disease (AD) modifying therapies move toward preclinical stages.

Objective

To investigate the relationship between AD biomarkers and subsequent change in cognition in a cohort of cognitively intact older adults.

Methods

84 cognitively normal subjects (mean age 72.0 years, 59% women) were recruited through the Massachusetts Alzheimer's Disease Research Center and the Harvard Aging Brain Study and followed over 3 years. Measurements of amyloid-β 1-42 (Aβ42), total Tau (t-Tau), and Tau phosphorylated at threonine 181 (p-Tau181) in the cerebrospinal fluid (CSF) at study entry were available in all cases. Baseline brain MRI, FDG-PET, and PiB-PET data were available in the

SUBMITTER: Dumurgier J 

PROVIDER: S-EPMC5773095 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature