Aspirin and incident depressive symptoms: A longitudinal cohort study over 8 years.

ABSTRACT:

Objective

Aspirin exhibits anti-atherosclerotic and anti-inflammatory properties-two potential risk factors for depression. The relationship between aspirin use and depression, however, remains unclear. We investigated whether the aspirin use is associated with a decreased incidence of depressive symptoms in a large North American cohort.

Methods

Data from the Osteoarthritis Initiative dataset, a multicenter, longitudinal study on community-dwelling adults was analyzed. Aspirin use was defined through self-report in the past 30 days and confirmed by a trained interviewer. Incident depressive symptoms were defined as a score of ≥16 in the 20-item Center for Epidemiologic Studies-Depression scale.

Results

A total of 137 participants (mean age 65 y, 55.5% female) were us

SUBMITTER: Veronese N 

PROVIDER: S-EPMC5773347 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature