An updated influenza A(H3N2) vaccine generates limited antibody responses to previously encountered antigens in children.

ABSTRACT:

Background

Influenza vaccination may provide a "back-boost" to antibodies against previously encountered strains. If the back-boost effect is common, this could allow more aggressive vaccine updates, as emerging variants would be expected to both elicit de-novo responses and boost pre-existing responses against recently circulating strains. Here we used the emergence of an antigenically novel A(H3N2) strain to determine whether an antigenically updated vaccine boosted antibodies against historical strains.

Methods

We performed hemagglutination-inhibition (HI) assays on pre- and post-vaccination sera from 124 children 5-17 years old who received 2015-2016 inactivated influenza vaccine, containing an antigenically updated A(H3N2) strain. We evaluated the mean fold increase in

SUBMITTER: Florek KR 

PROVIDER: S-EPMC5773382 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature