The host response in critically ill sepsis patients on statin therapy: a prospective observational study.

ABSTRACT:

Background

Statins can exert pleiotropic anti-inflammatory, vascular protective and anticoagulant effects, which in theory could improve the dysregulated host response during sepsis. We aimed to determine the association between prior statin use and host response characteristics in critically ill patients with sepsis.

Methods

We performed a prospective observational study in 1060 patients admitted with sepsis to the mixed intensive care units (ICUs) of two hospitals in the Netherlands between January 2011 and July 2013. Of these, 351 patients (33%) were on statin therapy before admission. The host response was evaluated by measuring 23 biomarkers providing insight into key pathways implicated in sepsis pathogenesis and by analyzing whole-blood leukocyte transcriptomes in sam

SUBMITTER: Wiewel MA 

PROVIDER: S-EPMC5773465 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature