Ontology highlight
ABSTRACT:
SUBMITTER: Miao Y
PROVIDER: S-EPMC5773557 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Nature communications 20180118 1
The optimal expression of endothelial nitric oxide synthase (eNOS), the hallmark of endothelial homeostasis, is vital to vascular function. Dynamically regulated by various stimuli, eNOS expression is modulated at transcriptional, post-transcriptional, and post-translational levels. However, epigenetic modulations of eNOS, particularly through long non-coding RNAs (lncRNAs) and chromatin remodeling, remain to be explored. Here we identify an enhancer-associated lncRNA that enhances eNOS expressi ...[more]