Current pesticide dietary risk assessment in light of comparable animal study NOAELs after chronic and short-termed exposure durations.

ABSTRACT: Dietary risk assessment (DRA) of pesticides includes the estimation of chronic and acute exposures from crop residues, but assesses acute exposures only for pesticides with an acute reference dose (ARfD). Acute estimation uses high percentiles of food consumption surveys which are considerably higher than per capita lifetime averaged food consumption values which are used for chronic estimations. Assessing acute risks only for pesticides with an ARfD tacitly assumes that chronic risk assessment covers also intermittent occurring exposures which could significantly exceed chronic estimates. The present investigation conducted on 2200 rat studies from 436 pesticides provides evidence demonstrating that pesticides with and without ARfD have no-observed-adverse-effect levels (NOAELs) which rem

SUBMITTER: Zarn JA 

PROVIDER: S-EPMC5773667 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature