Network Features and Dynamical Landscape of Naive and Primed Pluripotency.

ABSTRACT: Although the broad and unique differentiation potential of pluripotent stem cells relies on a complex transcriptional network centered around Oct4, Sox2, and Nanog, two well-distinct pluripotent states, called "naive" and "primed", have been described in vitro and markedly differ in their developmental potential, their expression profiles, their signaling requirements, and their reciprocal conversion. Aiming to determine the key features that segregate and coordinate these two states, data-driven optimization of network models is performed to identify relevant parameter regimes and reduce network complexity to its core structure. Decision dynamics of optimized networks is characterized by signal-dependent multistability and strongly asymmetric transitions among naive, primed, and nonplurip

SUBMITTER: Pfeuty B 

PROVIDER: S-EPMC5773751 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature