Prognostic value of PD-L1 expression in combination with CD8⁺ TILs density in patients with surgically resected non-small cell lung cancer.

ABSTRACT: To investigate the prognostic value of PD-L1 expression combined with CD8⁺ TILs density in patients with resected NSCLC and correlations with clinicopathological features. We retrospectively enrolled 178 patients with resected NSCLC from 2011 to 2015. All surgical primary and 58 matched metastatic lymph node specimens were tested for PD-L1, CD8⁺ TILs, and oncogenic alterations. PD-L1⁺ was detected in 71 (39.9%) and CD8^high TILs in 74 (41.6%) cases. Smoking, SqCC, and EGFR^- were associated with both PD-L1⁺ and CD8^high TILs. Patients with CD8^high TILs had longer OS (P = 0.012). PD-L1^- was significantly associated with longer OS in patients with oncogenic alterations (P = 0.047). By multivariate

SUBMITTER: Yang H 

PROVIDER: S-EPMC5773962 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature