Ontology highlight
ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC5773975 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Zhang Xiaojing X Peng Yin Y Huang Yong Y Yang Mengting M Yan Ruibin R Zhao Yanqiu Y Cheng Yulan Y Liu Xi X Deng Shiqi S Feng Xianling X Lin Huijuan H Yu Huimin H Chen Si S Zhao Zhenfu Z Li Shanni S Li Kuan K Wang Liang L Wei Yanjie Y He Zhendan Z Fan Xinmin X Meltzer Stephen J SJ Li Song S Jin Zhe Z
Cancer medicine 20171213 1
SMG-1,a member of the phosphoinositide kinase-like kinase family, functioned as a tumor suppressor gene. However, the role of SMG-1 in GC remain uncharacterized. In this study, regulation of SMG-1 by miR-192 and-215, along with the biological effects of this modulation, were studied in GC. We used gene microarrays to screening and luciferase reporter assays were to verify the potential targets of miR-192 and-215. Tissue microarrays analyses were applied to measure the levels of SMG-1 in GC tissu ...[more]