Radiation-induced pulmonary gene expression changes are attenuated by the CTGF antibody Pamrevlumab.

ABSTRACT:

Background

Fibrosis is a delayed side effect of radiation therapy (RT). Connective tissue growth factor (CTGF) promotes the development of fibrosis in multiple settings, including pulmonary radiation injury.

Methods

To better understand the cellular interactions involved in RT-induced lung injury and the role of CTGF in these responses, microarray expression profiling was performed on lungs of irradiated and non-irradiated mice, including mice treated with the anti-CTGF antibody pamrevlumab (FG-3019). Between group comparisons (Welch's t-tests) and principal components analyses were performed in Genespring.

Results

At the mRNA level, the ability of pamrevlumab to prolong survival and ameliorate RT-induced radiologic, histologic and functional lung deficits was correla

SUBMITTER: Sternlicht MD 

PROVIDER: S-EPMC5774112 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature