A 13-year real-life study on efficacy, safety and biological effects of Vespula venom immunotherapy.

ABSTRACT:

Background

Hymenoptera venom immunotherapy (VIT) is a clinically effective treatment. However, little is known about its long-term clinical efficacy and biological effects. Several mechanisms have been proposed to account for VIT efficacy, including reduction of specific IgE and induction of allergen-specific IgG₄, but the overall picture remains elusive. We investigated Vespula VIT clinical efficacy up to 8 years after discontinuation and the kinetics of Vespula-specific IgE and IgG₄. Out of 686 consecutive patients we retrospectively selected and analysed a series of 23 patients with Vespula allergy that underwent a 5-year IT course, followed by a prolonged follow-up.

Methods

Clinical efficacy of VIT was assessed as number

SUBMITTER: Albanesi M 

PROVIDER: S-EPMC5774115 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature