Combination Immunotherapy for Type 1 Diabetes.

ABSTRACT: PURPOSE OF REVIEW:Type 1 diabetes (T1D) is an autoimmune disease marked by β-cell destruction. Immunotherapies for T1D have been investigated since the 1980s and have focused on restoration of tolerance, T cell or B cell inhibition, regulatory T cell (Treg) induction, suppression of innate immunity and inflammation, immune system reset, and islet transplantation. The purpose of this review is to provide an overview and lessons learned from single immunotherapy trials, describe recent and ongoing combination immunotherapy trials, and provide perspectives on strategies for future combination clinical interventions aimed at preserving insulin secretion in T1D. RECENT FINDINGS:Combination immunotherapies have had mixed results in improving short-term glycemic control and insulin secretion in r

SUBMITTER: Bone RN 

PROVIDER: S-EPMC5774222 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature