Osmotic Shifts, Cerebral Edema, and Neurologic Deterioration in Severe Hepatic Encephalopathy.

ABSTRACT: OBJECTIVES:We sought to determine the effect of acute electrolyte and osmolar shifts on brain volume and neurologic function in patients with liver failure and severe hepatic encephalopathy. DESIGN:Retrospective analysis of brain CT scans and clinical data. SETTING:Tertiary care hospital ICUs. PATIENTS:Patients with acute or acute-on-chronic liver failure and severe hepatic encephalopathy. INTERVENTIONS:Clinically indicated CT scans and serum laboratory studies. MEASUREMENTS AND MAIN RESULTS:Change in intracranial cerebrospinal fluid volume between sequential CT scans was measured as a biomarker of acute brain volume change. Corresponding changes in serum osmolality, chemistry measurements, and Glasgow Coma Scale were determined. Associations with cerebrospinal fluid volume change and Glas

SUBMITTER: Liotta EM 

PROVIDER: S-EPMC5774236 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature