Patient-derived organoid models help define personalized management of gastrointestinal cancer.

ABSTRACT:

Background

The prognosis of patients with different gastrointestinal cancers varies widely. Despite advances in treatment strategies, such as extensive resections and the addition of new drugs to chemotherapy regimens, conventional treatment strategies have failed to improve survival for many tumours. Although promising, the clinical application of molecularly guided personalized treatment has proven to be challenging. This narrative review focuses on the personalization of cancer therapy using patient-derived three-dimensional 'organoid' models.

Methods

A PubMed search was conducted to identify relevant articles. An overview of the literature and published protocols is presented, and the implications of these models for patients with cancer, surgeons and oncologists are exp

SUBMITTER: Aberle MR 

PROVIDER: S-EPMC5774241 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature