Sonic Hedgehog and WNT Signaling Promote Adrenal Gland Regeneration in Male Mice.

ABSTRACT: The atrophy and hypofunction of the adrenal cortex following long-term pharmacologic glucocorticoid therapy is a major health problem necessitating chronic glucocorticoid replacement that often prolongs the ultimate return of endogenous adrenocortical function. Underlying this functional recovery is anatomic regeneration, the cellular and molecular mechanisms of which are poorly understood. Investigating the lineage contribution of cortical Sonic hedgehog (Shh)+ progenitor cells and the SHH-responsive capsular Gli1+ cells to the regenerating adrenal cortex, we observed a spatially and temporally bimodal contribution of both cell types to adrenocortical regeneration following cessation of glucocorticoid treatment. First, an early repopulation of the cortex is defined by a marked delaminatio

SUBMITTER: Finco I 

PROVIDER: S-EPMC5774245 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature