Region-Specific Association of Subjective Cognitive Decline With Tauopathy Independent of Global β-Amyloid Burden.

ABSTRACT:

Importance

The ability to explore associations between reports of subjective cognitive decline (SCD) and biomarkers of early Alzheimer disease (AD) pathophysiologic processes (accumulation of neocortical β-amyloid [Aβ] and tau) provides an important opportunity to understand the basis of SCD and AD risk.

Objective

To examine associations between SCD and global Aβ and tau burdens in regions of interest in clinically healthy older adults.

Design, setting, and participants

This imaging substudy of the Harvard Aging Brain Study included 133 clinically healthy older participants (Clinical Dementia Rating Scale global scores of 0) participating in the Harvard Aging Brain Study who underwent cross-sectional flortaucipir F 18 (previously known as AV 1451, T807) positron emiss

SUBMITTER: Buckley RF 

PROVIDER: S-EPMC5774633 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature