Brain functional BOLD perturbation modelling for forward fMRI and inverse mapping.

ABSTRACT:

Purpose

To computationally separate dynamic brain functional BOLD responses from static background in a brain functional activity for forward fMRI signal analysis and inverse mapping.

Methods

A brain functional activity is represented in terms of magnetic source by a perturbation model: χ = χ0 +δχ, with δχ for BOLD magnetic perturbations and χ0 for background. A brain fMRI experiment produces a timeseries of complex-valued images (T2* images), whereby we extract the BOLD phase signals (denoted by δP) by a complex division. By solving an inverse problem, we reconstruct the BOLD δχ dataset from the δP dataset, and the brain χ distribution from a (unwrapped) T2* phase image. Given a 4D dataset of task BOLD fMRI, we implement brain functional mapping by temporal correlation anal

SUBMITTER: Chen Z 

PROVIDER: S-EPMC5774799 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature