Ontology highlight
ABSTRACT:
SUBMITTER: Garofalo S
PROVIDER: S-EPMC5774898 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
eLife 20171229
In glioma, microglia and infiltrating macrophages are exposed to factors that force them to produce cytokines and chemokines, which contribute to tumor growth and to maintaining a pro-tumorigenic, immunosuppressed microenvironment. We demonstrate that housing glioma-bearing mice in enriched environment (EE) reverts the immunosuppressive phenotype of infiltrating myeloid cells, by modulating inflammatory gene expression. Under these conditions, the branching and patrolling activity of myeloid cel ...[more]