Oxidative Post-Translational Modifications of an Amyloidogenic Immunoglobulin Light Chain Protein.

ABSTRACT: Immunoglobulin light chain amyloidosis (AL) is a plasma cell disorder characterized by overproduction and deposition of monoclonal immunoglobulin (Ig) light chains (LC) or variable region fragments as amyloid fibrils in various organs and tissues. Much clinical evidence indicates that patients with AL amyloidosis sustain cardiomyocyte impairment and suffer from oxidative stress. We seek to understand the underlying biochemical pathways whose disruption or amplification during sporadic or sustained disease states leads to harmful physiological consequences and to determine the detailed structures of intermediates and products that serve as signposts for the biochemical changes and represent potential biomarkers. In this study, matrix-assisted laser desorption/ionization mass spectrometry pr

SUBMITTER: Lu Y 

PROVIDER: S-EPMC5774984 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature